Structure of PDB 5w4t Chain D Binding Site BS02

Receptor Information
>5w4t Chain D (length=315) Species: 7955 (Danio rerio) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MNQPPRFQNYFFQSYLLVYEDTPVGTSITQLQAVDPDGEPLIFGVVGEEA
MRYFAVQGTTGVVWLRQPLDREAKSEMQVEFTVSDSQGVVKDTVNIQIGD
VNDNAPSFYNQPYAIQIPENTPVGTSVFMVNATDPDQGVGGSVLFSFQPP
SQFFSIDGARGIVTVTRALDYETTIAYQLTVNATDQDKRRPLSSLANLAI
TITDIQDMDPIFTNLPYSTNIMEDAPPGYEVRKIRAIDQDLGRPRGIGYT
IISGNTNSMFALDYISGSLTVSGQLDRENPLYSSGFIITVKATELNDDRT
PSSATVTTTFTILLI
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain5w4t Chain D Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5w4t Zooming in on Cadherin-23: Structural Diversity and Potential Mechanisms of Inherited Deafness.
Resolution2.65 Å
Binding residue
(original residue number in PDB)		Q205 M207 D237 D239 E293
Binding residue
(residue number reindexed from 1)		Q206 M208 D238 D240 E294
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
Biological Process
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5w4t, PDBe:5w4t, PDBj:5w4t
PDBsum5w4t
PubMed30033219
UniProtF1R7G8

[Back to BioLiP]