Structure of PDB 5vhd Chain D Binding Site BS02

Receptor Information
>5vhd Chain D (length=795) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RDSEYLLQENEPDATLDQQLLEDLQKKKTDLRYIEMQRFREKLPSYGMQK
ELVNMIDNHQVTVISGETGCGKTTQVTQFILDNYIERGKGSACRIVCTQP
RRISAISVAERVAAERAESCGNGNSTGYQIRLQSRLPRKQGSILYCTTGI
ILQWLQSDPHLSSVSHIVLDEIHERNLQSDVLMTVVKDLLSYRPDLKVVL
MSATLNAEKFSEYFGNCPMIHIPGFTFPVVEYLLEDIIEKIRYVPEYYYE
AIYKERWPGYLRELRQRYSASTVDVVEMMDDEKVDLNLIAALIRYIVLEE
EDGAILVFLPGWDNISTLHDLLMSQVMFKSDKFIIIPLHSLMPTVNQTQV
FKRTPPGVRKIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQNNISTM
SAEWVSKANAKQRKGRAGRVQPGHCYHLYNSLRASLLDDYQLPEILRTPL
EELCLQIKILRLGGIAHFLSRLMDPPSNEAVLLSIKHLMELNALDKQEEL
TPLGVHLARLPVEPHIGKMILFGALFCCLDPVLTIAASLSFKDPFVIPLG
KEKVADARRKELAKDTKSDHLTVVNAFKGWEKAKQRGFRYEKDYCWEYFL
SSNTLQMLHNMKGQFAEHLLGAGFVSSRNPQDPESNINSDNEKIIKAVIC
AGLYPKVAKIRLNMVKVYTKTDGVVAIHPKSVNVEQTEFNYNWLIYHLKM
RTSSIYLYDCTEVSPYCLLFFGGDISIQKQETIAVDEWIIFQSPARIAHL
VKELRKELDILLQEKIESPHPVDWKDTKSRDCAVLSAIIDLIKTQ
Ligand information
Ligand IDALF
InChIInChI=1S/Al.4FH/h;4*1H/q+3;;;;/p-4
InChIKeyUYOMQIYKOOHAMK-UHFFFAOYSA-J
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		F[Al-](F)(F)F
FormulaAl F4
NameTETRAFLUOROALUMINATE ION
ChEMBL
DrugBankDB04444
ZINC
PDB chain5vhd Chain D Residue 1102 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5vhd Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36.
Resolution2.55 Å
Binding residue
(original residue number in PDB)		T234 E337 S559 R604 R607
Binding residue
(residue number reindexed from 1)		T68 E171 S371 R416 R419
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:5vhd, PDBe:5vhd, PDBj:5vhd
PDBsum5vhd
PubMed29899445
UniProtQ05B79|DHX36_BOVIN ATP-dependent DNA/RNA helicase DHX36 (Gene Name=DHX36)

[Back to BioLiP]