Structure of PDB 5utm Chain D Binding Site BS02

Receptor Information

>5utm Chain D (length=334) Species: 1311 (Streptococcus agalactiae)

VVKVGINGFGRIGRLAFRRIQNVEGVEVTRINDLTDPNMLAHLLKYDTTQ
GRFDGTVEVKEGGFEVNGQFVKVSAEREPANIDWATDGVEIVLEATGFFA
SKEKAEQHIHENGAKKVVITAPGGNDVKTVVFNTNHDILDGTETVISGAS
CTTNCLAPMAKALQDNFGVKQGLMTTIHAYTGDQMILDGPHRGGDLRRAR
AGAANIVPNSTGAAKAIGLVIPELNGKLDGAAQRVPVPTGSVTELVATLE
KDVTVEEVNAAMKAAANDSYGYTEDPIVSSDIVGISYGSLFDATQTKVQT
VDGNTLVKVVSWYDNEMSYTSQLVRTLEYFAKIA

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 5utm Chain D Residue 402

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5utm Mutant Structures of Streptococcus agalactiae GAPDH
• Resolution: 1.77 Å
• Binding residue (original residue number in PDB): I21 V24 V27
• Binding residue (residue number reindexed from 1): I20 V23 V26
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 1.2.1.-

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
• GO:0016491 oxidoreductase activity
• GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
• GO:0042802 identical protein binding
• GO:0046872 metal ion binding
• GO:0050661 NADP binding
• GO:0051287 NAD binding

Biological Process

• GO:0006006 glucose metabolic process
• GO:0006096 glycolytic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:5utm, PDBe:5utm, PDBj:5utm
• PDBsum: 5utm
• UniProt: Q9ALW2