Structure of PDB 5umd Chain D Binding Site BS02

Receptor Information
>5umd Chain D (length=247) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GRVIRGQRKGRGSIFKSHNHHRKGAAKLRHLDYCEKKGYIKGLVKDIIHD
PGRGAPLAKVIFKRTEKYGKKEELIIASEGMFTGQYISCGTKAPLSVGNI
LPIGKMPEGTLICNLEHRTGNRGTLVKASGCYATVVGQSEDGKKTKVRLP
SGAKKTIDAKARAMVGVVGAGGRIDKPILKAGVAHHKYRVKRNCWPKVRG
VAMNPVEHPHGGGNHQHIGHPSTVSRSAPAGQKVGLIAARRTGLLRG
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain5umd Chain A Residue 3921 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5umd Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		K198 R200
Binding residue
(residue number reindexed from 1)		K197 R199
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:0022626 cytosolic ribosome
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5umd, PDBe:5umd, PDBj:5umd
PDBsum5umd
PubMed28288098
UniProtQ8I3T9

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