Structure of PDB 5th6 Chain D Binding Site BS02

Receptor Information
>5th6 Chain D (length=217) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TDRQLAEEYLYRYGYTRVALGPALLLLQKQLSLPETGELDSATLKAMRTP
RCGVPDLGRFQTFEGDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFAL
WSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPG
IQGDAHFDDDELWSLGYSLFLVAAHEFGHALGLDHSSVPEALMYPMYRFT
EGPPLHKDDVNGIRHLY
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5th6 Chain D Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5th6 Biochemical characterization and structure determination of a potent, selective antibody inhibitor of human MMP9.
Resolution1.7 Å
Binding residue
(original residue number in PDB)		H175 D177 H190 H203
Binding residue
(residue number reindexed from 1)		H128 D130 H143 H156
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) H401 E402 H405 H411
Catalytic site (residue number reindexed from 1) H175 E176 H179 H185
Enzyme Commision number 3.4.24.35: gelatinase B.
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0031012 extracellular matrix

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5th6, PDBe:5th6, PDBj:5th6
PDBsum5th6
PubMed28235803
UniProtP14780|MMP9_HUMAN Matrix metalloproteinase-9 (Gene Name=MMP9)

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