Structure of PDB 5mra Chain D Binding Site BS02

Receptor Information
>5mra Chain D (length=167) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSM
LDRDMSGTMGFNEFKELWAVLNGWRQHFISFDTDRSGTVDPQELQKALTT
MGFRLSPQAVNSIAKRYSTNGKITFDDYIACCVKLRALTDSFRRRDTAQQ
GVVNFPYDDFIQCVMSV
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain5mra Chain D Residue 202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5mra Binding of doxorubicin to Sorcin impairs cell death and increases drug resistance in cancer cells.
Resolution3.74 Å
Binding residue
(original residue number in PDB)		D83 D85 T89
Binding residue
(residue number reindexed from 1)		D52 D54 T58
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) F95 G118 V120
Catalytic site (residue number reindexed from 1) F64 G87 V89
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding

View graph for
Molecular Function
External links
PDB RCSB:5mra, PDBe:5mra, PDBj:5mra
PDBsum5mra
PubMed28726784
UniProtP30626|SORCN_HUMAN Sorcin (Gene Name=SRI)

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