Structure of PDB 5ly2 Chain D Binding Site BS02
Receptor Information
>5ly2 Chain D (length=347) Species:
9606
(Homo sapiens) [
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LNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRA
SYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYC
TPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTIL
DLVEKESGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKS
WYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPF
DKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCS
CRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFL
Ligand information
>5ly2 Chain H (length=8) Species:
32630
(synthetic construct) [
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YNTKSGWR
Receptor-Ligand Complex Structure
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PDB
5ly2
Highly selective inhibition of histone demethylases by de novo macrocyclic peptides.
Resolution
2.43 Å
Binding residue
(original residue number in PDB)
A69 N86 D135 G170 Y175 Y177 H240 K241 M242 S288 N290 C308 R309 D311 M312
Binding residue
(residue number reindexed from 1)
A62 N79 D128 G163 Y168 Y170 H233 K234 M235 S281 N283 C301 R302 D304 M305
Enzymatic activity
Catalytic site (original residue number in PDB)
G170 Y177 H188 E190 H276 S288
Catalytic site (residue number reindexed from 1)
G163 Y170 H181 E183 H269 S281
Enzyme Commision number
1.14.11.66
: [histone H3]-trimethyl-L-lysine(9) demethylase.
1.14.11.69
: [histone H3]-trimethyl-L-lysine(36) demethylase.
External links
PDB
RCSB:5ly2
,
PDBe:5ly2
,
PDBj:5ly2
PDBsum
5ly2
PubMed
28382930
UniProt
O75164
|KDM4A_HUMAN Lysine-specific demethylase 4A (Gene Name=KDM4A)
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