Structure of PDB 5lgp Chain D Binding Site BS02

Receptor Information
>5lgp Chain D (length=342) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFK
DKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDR
IVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGN
MFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEY
FRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLV
HGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTL
SGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRY
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5lgp Transition state mimics are valuable mechanistic probes for structural studies with the arginine methyltransferase CARM1.
Resolution2.04 Å
Binding residue
(original residue number in PDB)		Q149 F153 Y154 N162 M163 E258 Y262 E267 K310 Q338 H415 Y417 N472 F475
Binding residue
(residue number reindexed from 1)		Q14 F18 Y19 N27 M28 E123 Y127 E132 K175 Q203 H280 Y282 N337 F340
Enzymatic activity
Catalytic site (original residue number in PDB) D166 E258 E267 H415
Catalytic site (residue number reindexed from 1) D31 E123 E132 H280
Enzyme Commision number 2.1.1.319: type I protein arginine methyltransferase.
Gene Ontology
Molecular Function
GO:0016274 protein-arginine N-methyltransferase activity
Biological Process
GO:0018216 peptidyl-arginine methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5lgp, PDBe:5lgp, PDBj:5lgp
PDBsum5lgp
PubMed28330993
UniProtQ9WVG6|CARM1_MOUSE Histone-arginine methyltransferase CARM1 (Gene Name=Carm1)

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