Structure of PDB 5jhq Chain D Binding Site BS02

Receptor Information

>5jhq Chain D (length=463) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SGALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRK
DVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARD
NWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAV
LTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGY
NRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVN
AMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPE
LRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCA
VASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHK
HGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQ
MGNEAVQQILSES

Ligand information

>5jhq Chain L (length=9) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

YRQSPDGAC

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	5jhq Tankyrase-1 Ankyrin Repeats Form an Adaptable Binding Platform for Targets of ADP-Ribose Modification.
Resolution	3.2 Å
Binding residue (original residue number in PDB)	R368 S370 L375 G378 Y379 L403 N408 Y412 H414 D432 W434 F436 E441
Binding residue (residue number reindexed from 1)	R189 S191 L196 G199 Y200 L224 N229 Y233 H235 D253 W255 F257 E262

Enzymatic activity

Enzyme Commision number

2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.

External links

PDB	RCSB:5jhq, PDBe:5jhq, PDBj:5jhq
PDBsum	5jhq
PubMed	27594684
UniProt	O95271\|TNKS1_HUMAN Poly [ADP-ribose] polymerase tankyrase-1 (Gene Name=TNKS)

[Back to BioLiP]