Structure of PDB 5jgf Chain D Binding Site BS02

Receptor Information
>5jgf Chain D (length=462) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HNYEDIAQEFIDFIYKNPTTYHVVSFFAELLDKHNFKYLSEKSNWQDSIG
EDGGKFYTIRNGTNLSAFILGKNWRAEKGVGVIGSHVDALTVKLKPVSFK
DTAEGYGRIAVAPYGGTLNELWLDRDLGIGGRLLYKKKGTNEIKSALVDS
TPLPVCRIPSLAPHFGKPAEGPFDKEDQTIPVIGFPTPDNEPPTDDEKKS
PLFGKHCIHLLRYVAKLAGVEVSELIQMDLDLFDVQKGTIGGIGKHFLFA
PRLDDRLCSFAAMIALICYAKDVNTEESDLFSTVTLYDNEEIGSLTRQGA
KGGLLESVVERSSSAFTKKPVDLHTVWANSIILSADVNHLYNPNFPEVYL
KNHFPVPNVGITLSLDPNGHMATDVVGTALVEELARRNGDKVQYFQIKNN
SRSGGTIGPSLASQTGARTIDLGIAQLSMHSIRAATGSKDVGLGVKFFNG
FFKHWRSVYDEF
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5jgf Chain D Residue 602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5jgf Structural Basis for Receptor-Mediated Selective Autophagy of Aminopeptidase I Aggregates
Resolution1.83 Å
Binding residue
(original residue number in PDB)		D303 E340 H479
Binding residue
(residue number reindexed from 1)		D254 E291 H430
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.11.22: aminopeptidase I.
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0015031 protein transport
GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway
Cellular Component
GO:0000324 fungal-type vacuole
GO:0005737 cytoplasm
GO:0005773 vacuole
GO:0034270 Cvt complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5jgf, PDBe:5jgf, PDBj:5jgf
PDBsum5jgf
PubMed27320913
UniProtP14904|AMPL_YEAST Vacuolar aminopeptidase 1 (Gene Name=APE1)

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