Structure of PDB 5hp3 Chain D Binding Site BS02
Receptor Information
>5hp3 Chain D (length=397) Species:
9606
(Homo sapiens) [
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TPSRQPIPSEGLQLHLPQVLADAVSRLVLGKFGDLTDNFSSPHARRKVLA
GVVMTTGTDVKDAKVISVSTGTKCINGEYMSDRGLALNDCHAEIISRRSL
LRFLYTQLELYLNNKDDQKRSIFQKSERGGFRLKENVQFHLYISTSPCGD
ARIFSPHEPILEEPADRHPNRKARGQLRTKIESGEGTIPVRSNASIQTWD
GVLQGERLLTMSCSDKIARWNVVGIQGSLLSIFVEPIYFSSIILGSLYHG
DHLSRAMYQRISNIEDLPPLYTLNKPLLSGISNAEARQPGKAPNFSVNWT
VGDSAIEVINATTGKDELGRASRLCKHALYCRWMRVHGKVPSHLLRSKIT
KPNVYHESKLAAKEYQAAKARLFTAFIKAGLGAWVEKPTEQDQFSLT
Ligand information
Ligand ID
ZN
InChI
InChI=1S/Zn/q+2
InChIKey
PTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
Software
SMILES
CACTVS 3.341
[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Zn+2]
Formula
Zn
Name
ZINC ION
ChEMBL
CHEMBL1236970
DrugBank
DB14532
ZINC
PDB chain
5hp3 Chain D Residue 802 [
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Receptor-Ligand Complex Structure
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PDB
5hp3
Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity.
Resolution
3.091 Å
Binding residue
(original residue number in PDB)
H394 C451 C516
Binding residue
(residue number reindexed from 1)
H91 C148 C213
Annotation score
1
Enzymatic activity
Enzyme Commision number
3.5.4.37
: double-stranded RNA adenine deaminase.
Gene Ontology
Molecular Function
GO:0003723
RNA binding
GO:0004000
adenosine deaminase activity
Biological Process
GO:0006396
RNA processing
View graph for
Molecular Function
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Biological Process
External links
PDB
RCSB:5hp3
,
PDBe:5hp3
,
PDBj:5hp3
PDBsum
5hp3
PubMed
27065196
UniProt
P78563
|RED1_HUMAN Double-stranded RNA-specific editase 1 (Gene Name=ADARB1)
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