Structure of PDB 5hp2 Chain D Binding Site BS02

Receptor Information

>5hp2 Chain D (length=397) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

TPSRQPIPSEGLQLHLPQVLADAVSRLVLGKFGDLTDNFSSPHARRKVLA
GVVMTTGTDVKDAKVISVSTGTKCINGEYMSDRGLALNDCHAEIISRRSL
LRFLYTQLELYLNNKDDQKRSIFQKSERGGFRLKENVQFHLYISTSPCGD
ARIFSPHEPILEEPADRHPNRKARGQLRTKIESGEGTIPVRSNASIQTWD
GVLQGERLLTMSCSDKIARWNVVGIQGSLLSIFVEPIYFSSIILGSLYHG
DHLSRAMYQRISNIEDLPPLYTLNKPLLSGISNAEARQPGKAPNFSVNWT
VGDSAIEVINATTGKDELGRASRLCKHALYCRWMRVHGKVPSHLLRSKIT
KPNVYHESKLAAKEYQAAKARLFTAFIKAGLGAWVEKPTEQDQFSLT

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

5hp2 Chain D Residue 802 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	5hp2 Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity.
Resolution	2.983 Å
Binding residue (original residue number in PDB)	H394 C451 C516
Binding residue (residue number reindexed from 1)	H91 C148 C213
Annotation score	1

Enzymatic activity

Enzyme Commision number

3.5.4.37: double-stranded RNA adenine deaminase.

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0004000	adenosine deaminase activity

	Biological Process
GO:0006396	RNA processing

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:5hp2, PDBe:5hp2, PDBj:5hp2
PDBsum	5hp2
PubMed	27065196
UniProt	P78563\|RED1_HUMAN Double-stranded RNA-specific editase 1 (Gene Name=ADARB1)

[Back to BioLiP]