Structure of PDB 5eiu Chain D Binding Site BS02

Receptor Information
>5eiu Chain D (length=132) Species: 9544,262724 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DHCARHGEKLLLFCQEDSKVICWLCERSQEHRGHHTFLMEEVAQEYHVKL
QTALEMLRQKQQEAETERNQVAKRVPKAPPEEKEALIARGKALGEQTQYM
RELISELEHRLQGSMMDLLQGVDGIIKRIENM
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5eiu Chain D Residue 702 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5eiu Mechanism of B-box 2 domain-mediated higher-order assembly of the retroviral restriction factor TRIM5 alpha.
Resolution1.908 Å
Binding residue
(original residue number in PDB)		C97 H100 C116 C119
Binding residue
(residue number reindexed from 1)		C3 H6 C22 C25
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) K221
Catalytic site (residue number reindexed from 1) K127
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
6.1.1.11: serine--tRNA ligase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:5eiu, PDBe:5eiu, PDBj:5eiu
PDBsum5eiu
PubMed27253059
UniProtP34945|SYS_THET2 Serine--tRNA ligase (Gene Name=serS);
Q0PF16|TRIM5_MACMU Tripartite motif-containing protein 5 (Gene Name=TRIM5)

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