Structure of PDB 5cdr Chain D Binding Site BS02

Receptor Information

>5cdr Chain D (length=189) Species: 158879 (Staphylococcus aureus subsp. aureus N315) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

KLADCSSKSPEECEIFLVEGDSAGGSTKSGRDSRTQAILPLRGKILNVEK
ARLDRILNNNEIRQMITAFGTGIGGDFDLAKARYHKIVIMTDADVDGAHI
RTLLLTFFYRFMRPLIEAGYVYIAQPPTGYKGLGEMNADQLWETTMNPEH
RALLQVKLEDAIEADQTFEMLMGDVVENRRQFIEDNAVY

Ligand information

>5cdr Chain F (length=16) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

agccgtagctacggct

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5cdr Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin.
Resolution	2.65 Å
Binding residue (original residue number in PDB)	E435 G459 K460 D512
Binding residue (residue number reindexed from 1)	E19 G43 K44 D96

Enzymatic activity

Enzyme Commision number

5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524	ATP binding

	Biological Process
GO:0006265	DNA topological change

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Molecular Function

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Biological Process

External links

PDB	RCSB:5cdr, PDBe:5cdr, PDBj:5cdr
PDBsum	5cdr
PubMed	26640131
UniProt	P66937\|GYRB_STAAN DNA gyrase subunit B (Gene Name=gyrB)

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