Structure of PDB 5b4w Chain D Binding Site BS02

Receptor Information
>5b4w Chain D (length=436) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PPTAFTPNGTYLQHLARDPTSGTLYLGATNFLFQLSPGLQLEATVSTGPV
LDSRDCLPPVMPDECPQAQPTNNPNQLLLVSPGALVVCGSVHQGVCEQRR
LGQLEQLLLRPERPGDTQYVAANDPAVSTVGLVAQGLAGEPLLFVGRGYT
SIPPITTRALWPPDPQAAFSYEETAKLAVGRLSEYSHHFVSAFARGASAY
FLFLRRDLQAQSRAFRAYVSRVCLRDQHYYSYVELPLACEGGRYGLIQAA
AVATSVAHGEVLFAAFSSAAPGASALCAFPLDEVDRLANRTRDACYTREG
RAEDGTEVAYIEYDVNSDCAQLPVDTLDAYPCGSDHTPSPMASRVPLEAT
PILEWPGIQLTAVAVTMEDGHTIAFLGDSQGQLHRVYLGPGSDGHPYSTQ
SIQQGSAVSRDLTFDGTFEHLYVMTQSTLLKVPVAS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5b4w Allosteric Inhibition of a Semaphorin 4D Receptor Plexin B1 by a High-Affinity Macrocyclic Peptide
Resolution2.6 Å
Binding residue
(original residue number in PDB)		Q240 S241 F294 T395 P396 I397 E399 D414 G415 H416 T417 L433 G434 S437
Binding residue
(residue number reindexed from 1)		Q211 S212 F263 T350 P351 I352 E354 D369 G370 H371 T372 L388 G389 S392
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0017154 semaphorin receptor activity
Biological Process
GO:0071526 semaphorin-plexin signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:5b4w, PDBe:5b4w, PDBj:5b4w
PDBsum5b4w
PubMed27984026
UniProtO43157|PLXB1_HUMAN Plexin-B1 (Gene Name=PLXNB1)

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