Structure of PDB 4znx Chain D Binding Site BS02

Receptor Information

>4znx Chain D (length=57) Species: 9606 (Homo sapiens)

TLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIP
SNYVAPV

Ligand information

>4znx Chain H (length=10) Species: 32630 (synthetic construct)

APPLPPRNRP

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4znx The role of water molecules in the binding of class I and II peptides to the SH3 domain of the Fyn tyrosine kinase.
• Resolution: 2.1 Å
• Binding residue (original residue number in PDB): Y91 Y93 D100 E116 G117 D118 W119 N136 Y137
• Binding residue (residue number reindexed from 1): Y7 Y9 D16 E32 G33 D34 W35 N52 Y53

Enzymatic activity

• Enzyme Commision number: 2.7.10.2: non-specific protein-tyrosine kinase.

External links

• PDB: RCSB:4znx, PDBe:4znx, PDBj:4znx
• PDBsum: 4znx
• PubMed: 27599862
• UniProt: P06241|FYN_HUMAN Tyrosine-protein kinase Fyn (Gene Name=FYN)