Structure of PDB 4xef Chain D Binding Site BS02

Receptor Information
>4xef Chain D (length=134) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ANLDRTDDLVYLNVMELVRAVLELKNELSQLPPEGYVVVVKNVGLTLRKL
IGSVDDLLPSLPSSSRTEIEGTQKLLNKDLAELINKMRLAQQNAVTSLSE
EAKRQMLTASHTLAVDAKNLLDAVDQAKVLANLA
Ligand information
Receptor-Ligand Complex Structure
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PDB4xef Structural Basis for the Interaction between Pyk2-FAT Domain and Leupaxin LD Repeats.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		G914 R918 N947 L950
Binding residue
(residue number reindexed from 1)		G44 R48 N77 L80
Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Gene Ontology
Molecular Function
GO:0004713 protein tyrosine kinase activity
Biological Process
GO:0006468 protein phosphorylation
GO:0007172 signal complex assembly
Cellular Component
GO:0005925 focal adhesion

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4xef, PDBe:4xef, PDBj:4xef
PDBsum4xef
PubMed26866573
UniProtQ14289|FAK2_HUMAN Protein-tyrosine kinase 2-beta (Gene Name=PTK2B)

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