Structure of PDB 4wqt Chain D Binding Site BS02

Receptor Information
>4wqt Chain D (length=1334) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKKEVRKVRIALASPEKIRSWSYGEVEKPETINYRTLKPERDGLFDERIF
GPIKDRRYRMGHIELATPAAHIWFVKDVPSKIGTLLDLSATELEQVLYFS
KYIVLDPKGAILNGVPVEKRQLLTDEEYRELRYGKQETYPLPPGVDALVK
DGEEVVKGQELAPGVVSRLDGVALYRFPRRVRVEYVPKDYRVQPHMNVVV
PEGARVEAGDKIVAAIDPEEEVIAEAEGVVHLHEPASILVVKARVYPFED
DVEVSTGDRVAPGDVLADGGKVKSDVYGRVEVDLVRNVVRVVESYDIDAR
MGAEAIQQLLKELDLEALEKELLEEMKHPSRARRAKARKRLEVVRAFLDS
GNRPEWMILEAVPVLPPDLRATSDLNDLYRRLINRNNRLKKLLAQGAPEI
IIRNEKRMLQEAVDALLDNGRRGAPVTNPGSDRPLRSLTDILSGKQGRFR
QNLLGKRVDYSGRSVIVVGPQLKLHQCGLPKRMALELFKPFLLKKMEEKG
IAPNVKAARRMLERQRDIKDEVWDALEEVIHGKVVLLNRAPTLHRLGIQA
FQPVLVEGQSIQLHPLVCEAFNADFDGDQMAVHVPLSSFAQAEARIQMLS
AHNLLSPASGEPLAKPSRDIILGLYYITQVRKEKKGAGLEFATPEEALAA
HERGEVALNAPIKVAGRETSVGRLKYVFANPDEALLAVAHGIVDLQDVVT
VRYMGKRLETSPGRILFARIVAEAVEDEKVAWELIQLDVPQEKNSLKDLV
YQAFLRLGMEKTARLLDALKYYGFTFSTTSGITIGIDDAVIPEEKKQYLE
EADRKLLQIEQAYEMGFLTDRERYDQILQLWTETTEKVTQAVFKNFEENY
PFNPLYVMAQSGARGNPQQIRQLCGLRGLMQKPSGETFEVPVRSSFREGL
TVLEYFISSHGARKGGADTALRTADSGYLTRKLVDVTHEIVVREADCGTT
NYISVPLFQPDEVTRSLRLRKRADIEAGLYGRVLAREVEVLGVRLEEGRY
LSMDDVHLLIKAAEAGEIQEVPVRSPLTCQTRYGVCQKCYGYDLSMARPV
SIGEAVGIVAAQSIGEPGTQLTMRTFHTGGVAGAADITQGLPRVIELFEA
RRPKAKAVISEIDGVVRIEETEEKLSVFVESEGFSKEYKLPKEARLLVKD
GDYVEAGQPLTRGAIDPHQLLEAKGPEAVERYLVEEIQKVYRAQGVKLHD
KHIEIVVRQMMKYVEVTDPGDSRLLEGQVLEKWDVEALNERLIAEGKTPV
AWKPLLMGVTKSALSTKSWLSAASFQNTTHVLTEAAIAGKKDELIGLKEN
VILGRLIPAGTGSDFVRFTQVVDQKTLKAIEEAR
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain4wqt Chain D Residue 2002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4wqt The Ratcheted and Ratchetable Structural States of RNA Polymerase Underlie Multiple Transcriptional Functions.
Resolution4.4 Å
Binding residue
(original residue number in PDB)		D739 D741 D743
Binding residue
(residue number reindexed from 1)		D574 D576 D578
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4wqt, PDBe:4wqt, PDBj:4wqt
PDBsum4wqt
PubMed25601758
UniProtQ8RQE8|RPOC_THET8 DNA-directed RNA polymerase subunit beta' (Gene Name=rpoC)

[Back to BioLiP]