Structure of PDB 4wqs Chain D Binding Site BS02

Receptor Information
>4wqs Chain D (length=1151) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KKEVRKVRIALASPEKIRSWSYGEVEKPETINYRTLKPERDGLFDERIFG
PIKDYECACGKYKRQRFEGKVCERCGVEVTKSIVRRYRMGHIELATPAAH
IWFVKDVPSKIGTLLDLSATELEQVLYFSKYIVLDPKGAILNGVPVEKRQ
LLTDEEYRELRYARMGAEAIQQLLKELDLEALEKELLEEMKHPSRARRAK
ARKRLEVVRAFLDSGNRPEWMILEAVPVLPPDLRPMVQVDGGRFATSDLN
DLYRRLINRNNRLKKLLAQGAPEIIIRNEKRMLQEAVDALLDNGRRGAPV
TNPGSDRPLRSLTDILSGKQGRFRQNLLGKRVDYSGRSVIVVGPQLKLHQ
CGLPKRMALELFKPFLLKKMEEKGIAPNVKAARRMLERQRDIKDEVWDAL
EEVIHGKVVLLNRAPTLHRLGIQAFQPVLVEGQSIQLHPLVCEAFNADFD
GDQMAVHVPLSSFAQAEARIQMLSAHNLLSPASGEPLAKPSRDIILGLYY
ITQVRKEKKGAGLEFATPEEALAAHERGEVALNAPIKVAGRETSVGRLKY
VFANPDEALLAVAHGIVDLQDVVTVRYMGKRLETSPGRILFARIVAEAVE
DEKVAWELIQLDVPQEKNSLKDLVYQAFLRLGMEKTARLLDALKYYGFTF
STTSGITIGIDDAVIPEEKKQYLEEADRKLLQIEQAYEMGFLTDRERYDQ
ILQLWTETTEKVTQAVFKNFEENYPFNPLYVMAQSGARGNPQQIRQLCGL
RGLMQKPSGETRSSFREGLTVLEYFISSHGARKGGADTALRTADSGYLTR
KLVDVTHEIVVREADCGTTNYISVPLFQPDEVTRSLRLRKRADIEAGLYG
RVLAREVEVLGVRLEEGRYLSMDDVHLLIKAAEAGEIQEVPVRSPLTCQT
RYGVCQKCYGYDLSMARPVSIGEAVGIVAAQSIGEPGTQLTMRTFHTGGV
AGAADITQGLPRVIELFEARRPKAAIDPHQLLEAKGPEAVERYLVEEIQK
VYRAQGVKLHDKHIEIVVRQMMKYVEVTDPGDSRLLEGQVLEKWDVEALN
ERLIAEGKTPVAWKPLLMGVTKSALSTKSWLSAASFQNTTHVLTEAAIAG
KKDELIGLKENVILGRLIPAGTGSDFVRFTQVVDQKTLKAIEEARKEAVE
A
Ligand information
Receptor-Ligand Complex Structure
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PDB4wqs The Ratcheted and Ratchetable Structural States of RNA Polymerase Underlie Multiple Transcriptional Functions.
Resolution4.306 Å
Binding residue
(original residue number in PDB)		K54 Q529 V530 D531 Q611 R704 A705 P706 N737 A738 D739 D741 G742 D743 Q744
Binding residue
(residue number reindexed from 1)		K53 Q238 V239 D240 Q320 R413 A414 P415 N446 A447 D448 D450 G451 D452 Q453
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4wqs, PDBe:4wqs, PDBj:4wqs
PDBsum4wqs
PubMed25601758
UniProtQ8RQE8|RPOC_THET8 DNA-directed RNA polymerase subunit beta' (Gene Name=rpoC)

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