Structure of PDB 4ttj Chain D Binding Site BS02
Receptor Information
>4ttj Chain D (length=237) Species:
562
(Escherichia coli) [
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ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTG
TYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKL
RDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARV
GNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTIC
TVSAHIRTHEQTTAAEAQTTFNDMIKIALESVLLGDK
Ligand information
Ligand ID
PO4
InChI
InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
InChIKey
NBIIXXVUZAFLBC-UHFFFAOYSA-K
SMILES
Software
SMILES
CACTVS 3.341
[O-][P]([O-])([O-])=O
ACDLabs 10.04
[O-]P([O-])([O-])=O
OpenEye OEToolkits 1.5.0
[O-]P(=O)([O-])[O-]
Formula
O4 P
Name
PHOSPHATE ION
ChEMBL
DrugBank
DB14523
ZINC
PDB chain
4ttj Chain D Residue 301 [
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Receptor-Ligand Complex Structure
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PDB
4ttj
Crystallographic snapshots of ligand binding to hexameric purine nucleoside phosphorylase and kinetic studies give insight into the mechanism of catalysis.
Resolution
1.874 Å
Binding residue
(original residue number in PDB)
G20 R87 G89 S90
Binding residue
(residue number reindexed from 1)
G20 R87 G89 S90
Annotation score
1
Enzymatic activity
Catalytic site (original residue number in PDB)
H4 R24 R43 R87 S203
Catalytic site (residue number reindexed from 1)
H4 R24 R43 R87 S203
Enzyme Commision number
2.4.2.1
: purine-nucleoside phosphorylase.
Gene Ontology
Molecular Function
GO:0003824
catalytic activity
GO:0004731
purine-nucleoside phosphorylase activity
GO:0016757
glycosyltransferase activity
GO:0016763
pentosyltransferase activity
GO:0042802
identical protein binding
GO:0047975
guanosine phosphorylase activity
Biological Process
GO:0006139
nucleobase-containing compound metabolic process
GO:0006152
purine nucleoside catabolic process
GO:0006974
DNA damage response
GO:0009116
nucleoside metabolic process
GO:0009164
nucleoside catabolic process
GO:0019686
purine nucleoside interconversion
GO:0042278
purine nucleoside metabolic process
Cellular Component
GO:0005737
cytoplasm
GO:0005829
cytosol
GO:0016020
membrane
View graph for
Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:4ttj
,
PDBe:4ttj
,
PDBj:4ttj
PDBsum
4ttj
PubMed
30337572
UniProt
P0ABP8
|DEOD_ECOLI Purine nucleoside phosphorylase DeoD-type (Gene Name=deoD)
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