Structure of PDB 4riw Chain D Binding Site BS02

Receptor Information

>4riw Chain D (length=297) Species: 9606 (Homo sapiens)

LVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEK
VKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQ
LITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRD
LAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESIL
HRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPP
ICTIDVYMIMRKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGD

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 4riw Chain D Residue 1002

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4riw Structural analysis of the EGFR/HER3 heterodimer reveals the molecular basis for activating HER3 mutations.
• Resolution: 3.1 Å
• Binding residue (original residue number in PDB): N818 D831
• Binding residue (residue number reindexed from 1): N155 D168
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): D813 A815 R817 N818 D831 G850
• Catalytic site (residue number reindexed from 1): D150 A152 R154 N155 D168 G187
• Enzyme Commision number: 2.7.10.1: receptor protein-tyrosine kinase.

Gene Ontology

Molecular Function

• GO:0004672 protein kinase activity
• GO:0004713 protein tyrosine kinase activity
• GO:0005524 ATP binding

Biological Process

• GO:0006468 protein phosphorylation

External links

• PDB: RCSB:4riw, PDBe:4riw, PDBj:4riw
• PDBsum: 4riw
• PubMed: 25468994
• UniProt: P00533|EGFR_HUMAN Epidermal growth factor receptor (Gene Name=EGFR)