Structure of PDB 4peg Chain D Binding Site BS02
Receptor Information
>4peg Chain D (length=349) Species:
5759
(Entamoeba histolytica) [
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QIQHIAIVGCVHGKYREMYRQLSEYEKSTGKEISFVICTGDMQTLRYEAD
LVYLKVPPKYKQMGDFHLYYEGKEKAPYLTLFIGGNHESSNVLLHLYNGG
FVCFNMYYLGVCSCININGLRIVGVSGIYKSFDEKKPYTYPPSPNDVVSL
FHTRNYVIQMLSNLSQSSQIDISLSHDWPQGIVMKGNYKQLYRFQPGFKK
DGASLGSPINKVILNTLKPKYWISGHMHCEYHAEEGPTHFIALGKIGYKN
AISYLDLPLKQKTDLEYDKDWVCNLIMTWPAFSNKAQFPDLSYSISELLS
KRTKELDKKIIELWEKYIGLKIIYDSDTFDIQFTSRRFYIEKIYNELNI
Ligand information
Ligand ID
5GP
InChI
InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
InChIKey
RQFCJASXJCIDSX-UUOKFMHZSA-N
SMILES
Software
SMILES
CACTVS 3.341
NC1=Nc2n(cnc2C(=O)N1)[C@@H]3O[C@H](CO[P](O)(O)=O)[C@@H](O)[C@H]3O
CACTVS 3.341
NC1=Nc2n(cnc2C(=O)N1)[CH]3O[CH](CO[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04
O=C1c2ncn(c2N=C(N)N1)C3OC(C(O)C3O)COP(=O)(O)O
OpenEye OEToolkits 1.5.0
c1nc2c(n1C3C(C(C(O3)COP(=O)(O)O)O)O)N=C(NC2=O)N
OpenEye OEToolkits 1.5.0
c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O)O)O)O)N=C(NC2=O)N
Formula
C10 H14 N5 O8 P
Name
GUANOSINE-5'-MONOPHOSPHATE
ChEMBL
CHEMBL283807
DrugBank
DB01972
ZINC
ZINC000002159505
PDB chain
4peg Chain D Residue 402 [
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Receptor-Ligand Complex Structure
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PDB
4peg
Structural basis of lariat RNA recognition by the intron debranching enzyme Dbr1.
Resolution
2.0 Å
Binding residue
(original residue number in PDB)
N90 H91 D205 H230 M231 H232
Binding residue
(residue number reindexed from 1)
N86 H87 D201 H226 M227 H228
Annotation score
4
Enzymatic activity
Enzyme Commision number
3.1.4.-
Gene Ontology
Molecular Function
GO:0003723
RNA binding
GO:0005506
iron ion binding
GO:0008270
zinc ion binding
GO:0008419
RNA lariat debranching enzyme activity
GO:0016787
hydrolase activity
GO:0030145
manganese ion binding
GO:0046872
metal ion binding
Biological Process
GO:0000375
RNA splicing, via transesterification reactions
GO:0000398
mRNA splicing, via spliceosome
GO:0006397
mRNA processing
Cellular Component
GO:0005634
nucleus
GO:0005737
cytoplasm
GO:0048471
perinuclear region of cytoplasm
View graph for
Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:4peg
,
PDBe:4peg
,
PDBj:4peg
PDBsum
4peg
PubMed
25123664
UniProt
C4M1P9
|DBR1_ENTH1 Lariat debranching enzyme (Gene Name=DBR1)
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