Structure of PDB 4m63 Chain D Binding Site BS02

Receptor Information

>4m63 Chain D (length=361) Species: 7227 (Drosophila melanogaster)

VAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHKDSYVGDEAQSKRG
ILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPK
ANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTV
PIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIK
EKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQ
PSFLGMEACGIHETTYNSIMKCAAAIRKDLYANTVLSGGTTMYPGIADRM
QKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYD
ESGPSIVHRKC

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 4m63 Chain D Residue 402

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4m63 The Bacterial Effector VopL Organizes Actin into Filament-like Structures.
• Resolution: 2.748 Å
• Binding residue (original residue number in PDB): D11 Q137
• Binding residue (residue number reindexed from 1): D7 Q124
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.6.4.-

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0005524 ATP binding
• GO:0016787 hydrolase activity

Biological Process

• GO:0000281 mitotic cytokinesis
• GO:0006338 chromatin remodeling
• GO:0007291 sperm individualization
• GO:0030723 ovarian fusome organization
• GO:0032507 maintenance of protein location in cell
• GO:0035148 tube formation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005856 cytoskeleton
• GO:0031011 Ino80 complex
• GO:0035060 brahma complex

External links

• PDB: RCSB:4m63, PDBe:4m63, PDBj:4m63
• PDBsum: 4m63
• PubMed: 24120140
• UniProt: P10987|ACT1_DROME Actin-5C (Gene Name=Act5C)