Structure of PDB 4kyi Chain D Binding Site BS02

Receptor Information
>4kyi Chain D (length=164) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ICQFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQTVCLDDT
TVKFEIWDTAGLERYHSLAPMYYRGAQAAIVVYDITNTDTFARAKNWVKE
LQRQASPNIVIALAGNKADLASKRAVEFQEAQAYADDNSLLFMETSAKTA
MNVNEIFMAIAKKL
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain4kyi Chain D Residue 302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4kyi Structural basis for the recruitment and activation of the Legionella phospholipase VipD by the host GTPase Rab5.
Resolution3.075 Å
Binding residue
(original residue number in PDB)		S35 T53
Binding residue
(residue number reindexed from 1)		S17 T35
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:4kyi, PDBe:4kyi, PDBj:4kyi
PDBsum4kyi
PubMed25114243
UniProtP51148|RAB5C_HUMAN Ras-related protein Rab-5C (Gene Name=RAB5C)

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