Structure of PDB 4iqj Chain D Binding Site BS02

Receptor Information
>4iqj Chain D (length=1185) Species: 271 (Thermus aquaticus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LKFAHLHQHTQFSLLDGAAKLQDLLKWVKETTPEDPALAMTDHGNLFGAV
EFYKKATAMGVKPIIGYEAYVAAESRFDRGYFHLTLLAKDFTGYQNLVRL
ASRAYLEGFYEKPRIDREILREHAQGLIALSGCLGAEIPQFILQDRLDLA
EARLNEDLSIFGDRFFIEIQNHGLPEQKKVNQVLKEFARKYGLGMVATND
GHYVRKEDARAHEVLLAIQSKTTLDDPERWRFPCDEFYVKTPEEMRAMLP
EAEWGDEPFDNTVEIARMCDVDLPIGDKMVYRIPRFPLPEGRTEAQYLRE
LTFLGLLRRYPDRITEAFYREVLRLLDERALAEALARVEEKAWEELRKRE
WTAEAILHRALYELSVIERMGFPGYFLIVQDYINWARGHGVSVGPGRGSA
AGSLVAYAVGITNIDPLRFGLLFERFLNPERVSMPDIDTDFSDRERDRVI
QYVRERYGEDKVAQIGTFGSLASKAALKDVARVYGIPHKKAEELAKLIPV
QFGKPKPLQEAIQVVPELRAEMEKDERIRQVIEVAMRLEGLNRHASVHAA
GVVIAAEPLTDLVPLMRDQEGRPVTQYDMGAVEALGLLKMDFLGLRTLTF
LDEARRIVKESKGVELDYDRLPLDDPKTFELLSRGETKGVFQLESGGMTA
TVRGLKPRRLEDIIALVSLYRPGPMEHIPTYIRRHHGQEPVSYAEFPHAE
KYLRPILDETYGIPVYQEQIMQIASQVAGYSLGEADLLRRAMGKKRVEEM
QKHRERFVRGAKERGVPEEEANRLFDMLEAFANYGFNKSHAAAYSLLSYQ
TAYVKAHYPVEFMAALLSVERHDSDKVAEYIRDARALGIPVLPPDVNRSG
FDFKVVGEEILFGLSAVKNVGEMAARAILEERERGGPFKSLGDFLKRLPE
QVVNKRALESLVKAGALDAFGDRARLLASLEPLLRWAAETRERGRSGLVG
LFAEVEEPPLVEASPLDEITMLRYEKEALGIYVSGHPVLRYPGLREVASC
TIEELSEFVRELPGKPKVLLSGMVEEVVRKPTRMMARFTLSDETGALEVV
VFGRAYEGVSPKLKEDIPLLVLAEVERVLAQAVWTLEEVLEAPKALEVEV
DHALLDEKGVARLKSLLDEHPGSLPVYLRVLGPFGEALFALREVRVGEEA
LGLLEAEGYRAYLVPDREVFLQGNGGGPKEEVVPF
Ligand information
Receptor-Ligand Complex Structure
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PDB4iqj Structure of PolIIIalpha-Tauc-DNA complex suggests an atomic model of the replisome
Resolution3.2 Å
Binding residue
(original residue number in PDB)		E519 K523 H849 D850 D852 Q928 R1067 E1078
Binding residue
(residue number reindexed from 1)		E492 K496 H822 D823 D825 Q901 R1037 E1048
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0003887 DNA-directed DNA polymerase activity
GO:0008408 3'-5' exonuclease activity
Biological Process
GO:0006260 DNA replication
GO:0071897 DNA biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4iqj, PDBe:4iqj, PDBj:4iqj
PDBsum4iqj
PubMed23478062
UniProtQ9XDH5|DPO3A_THEAQ DNA polymerase III subunit alpha (Gene Name=dnaE)

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