Structure of PDB 4gdp Chain D Binding Site BS02

Receptor Information
>4gdp Chain D (length=498) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KKVIIIGAGIAGLKAASTLHQNGIQDCLVLEARDRVGGRLQTVTGYQGRK
YDIGASWHHDTLTNPLFLEEAQLSLNDGRTRFVFDDDNFIYIDEERGRVD
HDKELLLEIVDNEMSKFAELEFHQHLGVSDCSFFQLVMKYLLQRRQFLTN
DQIRYLPQLCRYLELWHGLDWKLLSAKDTYFGHQGRAAFALNYDSVVQRI
AQSFPQNWLKLSCEVKSITREPSKNVTVNCEDGTVYNADYVIITVPQSVL
NLSVQPEKNLRGRIEFQPPLKPVIQDAFDKIHFGALGKVIFEFEECCWSN
ESSKIVTLANSTNEFVEIVRNAENLDELDSMLEREDSSVTCWSQPLFFVN
LSKSTGVASFMMLMQAPLTNHIESIREDKERLFSFFQPVLNKIMKCLDSE
DVIDGMRPIENIANANKPVLRNIIVSNWTRDPYSRGAYSACFPGDDPVDM
VVAMSNGQDSRIRFAGEHTIMDGAGCAYGAWESGRREATRISDLLKLE
Ligand information
Ligand IDPG4
InChIInChI=1S/C8H18O5/c9-1-3-11-5-7-13-8-6-12-4-2-10/h9-10H,1-8H2
InChIKeyUWHCKJMYHZGTIT-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341		OCCOCCOCCOCCO
OpenEye OEToolkits 1.5.0C(COCCOCCOCCO)O
FormulaC8 H18 O5
NameTETRAETHYLENE GLYCOL
ChEMBLCHEMBL1235254
DrugBank
ZINCZINC000001591820
PDB chain4gdp Chain D Residue 802 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4gdp Mechanistic and Structural Analyses of the Roles of Active Site Residues in Yeast Polyamine Oxidase Fms1: Characterization of the N195A and D94N Enzymes.
Resolution1.9998 Å
Binding residue
(original residue number in PDB)		W65 H67 W174 Y450
Binding residue
(residue number reindexed from 1)		W57 H59 W166 Y438
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) H67
Catalytic site (residue number reindexed from 1) H59
Enzyme Commision number 1.5.3.17: non-specific polyamine oxidase.
Gene Ontology
Molecular Function
GO:0003682 chromatin binding
GO:0016491 oxidoreductase activity
GO:0046592 polyamine oxidase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0052897 N8-acetylspermidine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity
GO:0052901 spermine oxidase activity
GO:0052903 N(1)-acetylpolyamine oxidase (3-acetamidopropanal-forming) activity
Biological Process
GO:0006338 chromatin remodeling
GO:0015940 pantothenate biosynthetic process
GO:0046208 spermine catabolic process
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4gdp, PDBe:4gdp, PDBj:4gdp
PDBsum4gdp
PubMed23034052
UniProtP50264|FMS1_YEAST Polyamine oxidase FMS1 (Gene Name=FMS1)

[Back to BioLiP]