Structure of PDB 4f2r Chain D Binding Site BS02

Receptor Information

>4f2r Chain D (length=583) Species: 235909 (Geobacillus kaustophilus HTA426)

KPLAKMAFTLADRVTEEMLADKAALVVEVVEENYHDAPIVGIAVVNEHGR
FFLRPETALADPQFVAWLGDETKKKSMFDSKRAAVALKWKGIELCGVSFD
LLLAAYLLDPAQGVDDVAAAAKMKQYEAVRPDEAVYGKGAKRAVPDEPVL
AEHLVRKAAAIWELERPFLDELRRNEQDRLLVELEQPLSSILAEMEFAGV
KVDTKRLEQMGKELAEQLGTVEQRIYELAGQEFNINSPKQLGVILFEKLQ
LPVLKKTKTGYSTSADVLEKLAPYHEIVENILHYRQLGKLQSTYIEGLLK
VVRPATKKVHTIFNQALTQTGRLSSTEPNLQNIPIRLEEGRKIRQAFVPS
ESDWLIFAADYSQIELRVLAHIAEDDNLMEAFRRDLDIHTKTAMDIFQVS
EDEVTPNMRRQAKAVNYGIVYGISDYGLAQNLNISRKEAAEFIERYFESF
PGVKRYMENIVQEAKQKGYVTTLLHRRRYLPDITSRNFNVRSFAERMAMN
TPIQGSAADIIKKAMIDLNARLKEERLQAHLLLQVHDELILEAPKEEMER
LCRLVPEVMEQAVTLRVPLKVDYHYGSTWYDAK

Ligand information

>4f2r Chain F (length=12)

atgggagtcagg

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4f2r Structural evidence for the rare tautomer hypothesis of spontaneous mutagenesis.
• Resolution: 1.63 Å
• Binding residue (original residue number in PDB): N527 N529 S530 Q533 K582 S585 T586 L610 T611 Q612 T613 S617 S618 T619 N622 Y714 I716 S717 Y719 G720 R771 N782 F786 R789 Q797
• Binding residue (residue number reindexed from 1): N234 N236 S237 Q240 K289 S292 T293 L317 T318 Q319 T320 S324 S325 T326 N329 Y421 I423 S424 Y426 G427 R478 N489 F493 R496 Q504

Enzymatic activity

• Enzyme Commision number: 2.7.7.7: DNA-directed DNA polymerase.

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003677 DNA binding
• GO:0003887 DNA-directed DNA polymerase activity
• GO:0008408 3'-5' exonuclease activity

Biological Process

• GO:0006139 nucleobase-containing compound metabolic process
• GO:0006260 DNA replication
• GO:0006261 DNA-templated DNA replication

External links

• PDB: RCSB:4f2r, PDBe:4f2r, PDBj:4f2r
• PDBsum: 4f2r
• UniProt: Q5KWC1