Structure of PDB 4cn2 Chain D Binding Site BS02

Receptor Information

>4cn2 Chain D (length=81) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

KHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDK
RQRNRCQYCRYQKCLAMGMKREAVQEERQRG

Ligand information

>4cn2 Chain B (length=17) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

attgacccttgaactca

Receptor-Ligand Complex Structure

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PDB	4cn2 Structural Basis of Natural Promoter Recognition by the Retinoid X Nuclear Receptor.
Resolution	2.069 Å
Binding residue (original residue number in PDB)	E153 G154 F158 R161 R184 N185 Q188 R191
Binding residue (residue number reindexed from 1)	E22 G23 F27 R30 R53 N54 Q57 R60
Binding affinity	PDBbind-CN: Kd=38nM

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003700	DNA-binding transcription factor activity
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding

	Biological Process
GO:0006355	regulation of DNA-templated transcription

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Biological Process

External links

PDB	RCSB:4cn2, PDBe:4cn2, PDBj:4cn2
PDBsum	4cn2
PubMed	25645674
UniProt	P19793\|RXRA_HUMAN Retinoic acid receptor RXR-alpha (Gene Name=RXRA)

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