Structure of PDB 4c2t Chain D Binding Site BS02

Receptor Information
>4c2t Chain D (length=645) Species: 1299 (Deinococcus radiodurans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SAGPDLLQALNPTQAQAADHFTGPALVIAGAGSGKTRTLIYRIAHLIGHY
GVHPGEILAVTFTNKAAAEMRERAGHLVPAGDLWMSTFHSAGVRILRTYG
EHIGLRRGFVIYDDDDQLDIIKEVMGSIPGIGAETQPRVIRGIIDRAKSN
LWTPDDLDRSREPFISGLPRDAAAEAYRRYEVRKKGQNAIDFGDLITETV
RLFKEVPGVLDKVQNKAKFIHVDEYQDTNRAQYELTRLLASRDRNLLVVG
DPDQSIYKFRGADIQNILDFQKDYPDAKVYMLEHNYRSSARVLEAANKLI
ENNTERLDKTLKPVKEAGQPVTFHRATDHRAEGDYVADWLTRLHGEGRAW
SEMAILYRTNAQSRVIEESLRRVQIPRIVGGVGFYDRREIRDILAYARLA
LNPADDVALRRIIGRPRRGIGDTALQKLMEWARTHHTSVLTACANAAEQN
ILDRGAHKATEFAGLMEAMSEAADNYEPAAFLRFVMETSGYLDLLRQEGQ
EGQVRLENLEELVSAAEEWSQDEANVSIADFLDDAALLSSDMRTAEDAVT
LMTLHNAKGLEFPVVFIVGVEQGLLPSKGAIAEGPSGIEEERRLFYVGIT
RAMERLLMTAAQNRMQFGKTNAAEDSAFLEDIEGLFDTVDPYGQP
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4c2t Structural and Mechanistic Insight Into DNA Unwinding by Deinococcus Radiodurans Uvrd.
Resolution3.997 Å
Binding residue
(original residue number in PDB)		R142 Y261 F263 R362 N364 A365 R422 G424 I425 S546 H571 N572
Binding residue
(residue number reindexed from 1)		R138 Y257 F259 R358 N360 A361 R417 G419 I420 S539 H555 N556
Binding affinityPDBbind-CN: Kd=0.36uM
Enzymatic activity
Catalytic site (original residue number in PDB) K38 T39 D227 E228 Q258 R617
Catalytic site (residue number reindexed from 1) K35 T36 D223 E224 Q254 R601
Enzyme Commision number 5.6.2.4: DNA 3'-5' helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016853 isomerase activity
GO:0016887 ATP hydrolysis activity
GO:0043138 3'-5' DNA helicase activity
GO:0046872 metal ion binding
Biological Process
GO:0000725 recombinational repair
GO:0032508 DNA duplex unwinding
Cellular Component
GO:0005829 cytosol
GO:0033202 DNA helicase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4c2t, PDBe:4c2t, PDBj:4c2t
PDBsum4c2t
PubMed24143224
UniProtQ9RTI9

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