Structure of PDB 3vd0 Chain D Binding Site BS02

Receptor Information

>3vd0 Chain D (length=200) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

EFIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQ
IKVSTPPPPGTAIRAMPVYKKAEHVTDVVKRCPNHELGRDFNEGQSAPAS
HLIRVEGNNLSQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSC
VGGMNRRPILIIITLEMRDGQVLGRRSFEGRICACPGRDRKADEDHYREQ

Ligand information

>3vd0 Chain H (length=11) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

caggcatgcct

Receptor-Ligand Complex Structure

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Structure summary

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PDB	3vd0 Structure of p73 DNA-binding domain tetramer modulates p73 transactivation.
Resolution	2.95 Å
Binding residue (original residue number in PDB)	N259 S261 R293 C295 A296 C297 R300
Binding residue (residue number reindexed from 1)	N147 S149 R181 C183 A184 C185 R188

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0000976	transcription cis-regulatory region binding
GO:0003677	DNA binding
GO:0003700	DNA-binding transcription factor activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription
GO:0006915	apoptotic process

	Cellular Component
GO:0005634	nucleus

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Cellular Component

External links

PDB	RCSB:3vd0, PDBe:3vd0, PDBj:3vd0
PDBsum	3vd0
PubMed	22474346
UniProt	O15350\|P73_HUMAN Tumor protein p73 (Gene Name=TP73)

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