Structure of PDB 3um2 Chain D Binding Site BS02

Receptor Information
>3um2 Chain D (length=375) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
THWFHRNPLKATAPVSFNYYGVVTGPSASKICNDLRSSRARLLELFTDLS
CNPEMMKNAADSYFSLLQGFINSLDESTQESKLRYIQNFKWTDTLQGQVP
SAQQDAVFELISMGFNVALWYTKYASRLAGKENITEDEAKEVHRSLKIAA
GIFKHLKESHLPKLITPAEKGRDLESRLIEAYVIQCQAEAQEVTIARAIE
LKHAPGLIAALAYETANFYQKADHTLSSLEPAYSAKWRKYLHLKMCFYTA
YAYCYHGETLLASDKCGEAIRSLQEAEKLYAKAEALCKEYGETKGPGPTV
KPSGHLFFRKLGNLVKNTLEKCQRENGFIYFQKIPTEAPQLELKANYGLV
EPIPFEFPPTSVQWTPETLAAFDLT
Ligand information
Receptor-Ligand Complex Structure
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PDB3um2 Two Distinct Binding Modes Define the Interaction of Brox with the C-Terminal Tails of CHMP5 and CHMP4B.
Resolution2.589 Å
Binding residue
(original residue number in PDB)		K141 H144 T195 R198 A199 H204 L208 Y348
Binding residue
(residue number reindexed from 1)		K140 H143 T194 R197 A198 H203 L207 Y347
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
Biological Process
GO:0007084 mitotic nuclear membrane reassembly
Cellular Component
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0016020 membrane
GO:0031965 nuclear membrane
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3um2, PDBe:3um2, PDBj:3um2
PDBsum3um2
PubMed22484091
UniProtQ5VW32|BROX_HUMAN BRO1 domain-containing protein BROX (Gene Name=BROX)

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