Structure of PDB 3twv Chain D Binding Site BS02
Receptor Information
>3twv Chain D (length=156) Species:
9606
(Homo sapiens) [
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NSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNR
VSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVA
DLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTD
IQDLLR
Ligand information
>3twv Chain H (length=11) Species:
9606
(Homo sapiens) [
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RTQPDGQSFRS
Receptor-Ligand Complex Structure
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PDB
3twv
Structural basis and sequence rules for substrate recognition by tankyrase explain the basis for cherubism disease.
Resolution
2.301 Å
Binding residue
(original residue number in PDB)
R525 S527 F532 G535 Y536 L560 Y569 H571 D589 W591 F593 E598 K602 K604
Binding residue
(residue number reindexed from 1)
R37 S39 F44 G47 Y48 L72 Y81 H83 D101 W103 F105 E110 K114 K116
Enzymatic activity
Enzyme Commision number
2.4.2.-
2.4.2.30
: NAD(+) ADP-ribosyltransferase.
External links
PDB
RCSB:3twv
,
PDBe:3twv
,
PDBj:3twv
PDBsum
3twv
PubMed
22153077
UniProt
Q9H2K2
|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)
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