Structure of PDB 3twt Chain D Binding Site BS02
Receptor Information
>3twt Chain D (length=160) Species:
9606
(Homo sapiens) [
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GAMGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAA
GYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAV
VNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKD
GDTDIQDLLR
Ligand information
>3twt Chain H (length=15) Species:
9606
(Homo sapiens) [
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PHLQRPPPIGQSFRS
Receptor-Ligand Complex Structure
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PDB
3twt
Structural basis and sequence rules for substrate recognition by tankyrase explain the basis for cherubism disease.
Resolution
1.85 Å
Binding residue
(original residue number in PDB)
R525 F532 G535 Y536 L560 N565 S568 Y569 H571 D589 W591 F593 E598 K604
Binding residue
(residue number reindexed from 1)
R41 F48 G51 Y52 L76 N81 S84 Y85 H87 D105 W107 F109 E114 K120
Enzymatic activity
Enzyme Commision number
2.4.2.-
2.4.2.30
: NAD(+) ADP-ribosyltransferase.
External links
PDB
RCSB:3twt
,
PDBe:3twt
,
PDBj:3twt
PDBsum
3twt
PubMed
22153077
UniProt
Q9H2K2
|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)
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