Structure of PDB 3tht Chain D Binding Site BS02

Receptor Information

>3tht Chain D (length=302) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

TLLRHEGIETVSYATQSLVVANGGLGNGVSRNQLLPVLEKCGLVDALLMP
PNKPYSFARYRTTEESKRAYVTLNGKEVVDDLGQKITLYLNFVEKVQWKE
LRPQALPPGLMVVEEIISSEEEKMLLESVDWTHRRVKHFGYLPDICESFL
EKWLRKGYIKHKPDQMTINQYEPGQGIPAHIDTHSAFEDEIVSLSLGSEI
VMDFKHPDGIAVPVMLPRRSLLVMTGESRYLWTHGITCRKFDTVQASESL
KSGIITSDVGDLTLSKRGLRTSFTFRKVRQTPCNCSYPLVCDSQRKENLY
FQ

Ligand information

Ligand ID

InChI

InChI=1S/Mn/q+2

InChIKey

WAEMQWOKJMHJLA-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mn+2]
CACTVS 3.341	[Mn++]

Formula

Name

MANGANESE (II) ION

PDB chain

3tht Chain D Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	3tht Crystal structure and RNA binding properties of the RNA recognition motif (RRM) and AlkB domains in human AlkB homolog 8 (ABH8), an enzyme catalyzing tRNA hypermodification.
Resolution	3.01 Å
Binding residue (original residue number in PDB)	H238 D240 H292
Binding residue (residue number reindexed from 1)	H180 D182 H234
Annotation score	1

Enzymatic activity

Enzyme Commision number

2.1.1.229: tRNA (carboxymethyluridine(34)-5-O)-methyltransferase.

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0003723	RNA binding

	Biological Process
GO:0070988	demethylation

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Molecular Function

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Biological Process

External links

PDB	RCSB:3tht, PDBe:3tht, PDBj:3tht
PDBsum	3tht
PubMed	22065580
UniProt	Q96BT7\|ALKB8_HUMAN Alkylated DNA repair protein alkB homolog 8 (Gene Name=ALKBH8)

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