Structure of PDB 3suf Chain D Binding Site BS02

Receptor Information
>3suf Chain D (length=183) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSVVIVGRINLSGDTAYAQQTRGEGCQETSQTGRDKNGEVQIVSTATQTF
LATSINGVLWTVYHGAGTRTIASPKGPVTQMYTNVDKDLVGWQAPRSLTP
CTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCP
AGHAVGIFRAAVCTRGVAKAVAFIPVESLETTM
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain3suf Chain D Residue 1202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3suf The Molecular Basis of Drug Resistance against Hepatitis C Virus NS3/4A Protease Inhibitors.
Resolution2.19 Å
Binding residue
(original residue number in PDB)		C1145 H1149
Binding residue
(residue number reindexed from 1)		C149 H153
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) H1057 D1081 G1137 S1139
Catalytic site (residue number reindexed from 1) H64 D88 G141 S143
Enzyme Commision number 3.4.21.98: hepacivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019087 transformation of host cell by virus

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Molecular Function
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Biological Process
External links
PDB RCSB:3suf, PDBe:3suf, PDBj:3suf
PDBsum3suf
PubMed22910833
UniProtA8DG50

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