Structure of PDB 3rmc Chain D Binding Site BS02

Receptor Information
>3rmc Chain D (length=890) Species: 12353 (Escherichia phage RB69) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKEFYLTVEQIGDSIFERYIDSNGRERTREVEYKPSLFAHCPESQATKYF
DIYGKPCTRKLFANMRDASQWIKRMEDIGLEALGMDDFKLAYLSDTYNYE
IKYDHTKIRVANFDIEVTSPDGFPEPSQAKHPIDAITHYDSIDDRFYVFD
LLNSPYGNVEEWSIEIAAKLQEQGGDEVPSEIIDKIIYMPFDNEKELLME
YLNFWQQKTPVILTGWNVESFAIPYVYNRIKNIFGESTAKRLSPHRKTRV
KVIEIITLFGISVLDYIDLYKKFSFTNQPSYSLDYISEFELNVGKLKYDG
PISKLRESNHQRYISYNIIAVYRVLQIDAKRQFINLSLDMGYYAKIQIQS
VFSPIKTWDAIIFNSLKEQNKVIPQGRSHPVQPYPGAFVKEPIPNRYKYV
MSFDLTSLYPSIIRQVNISPETIAGTFKVAPLHDYINAVAERPSDVYSCS
PNGMMYYKDRDGVVPTEITKVFNQRKEHKGYMLAAQRNGEIIKEALHNPN
LSVDEPLDVDYRFDFSDEIKEKIKKLSAKSLNEMLFRAQRTEVAGMTAQI
NRKLLINSLYGALGNVWFRYYDLRNATAITTFGQMALQWIERKVNEYLNE
VCGTEGEAFVLYGDTDSIYVSADKIIDKVGESKFRDTNHWVDFLDKFARE
RMEPAIDRGFREMCEYMNNKQHLMFMDREAIAGPPLGSKGIGGFWTGKKR
YALNVWDMEGTRYAEPKLKIMGLETQKSSTPKAVQKALKECIRRMLQEGE
ESLQEYFKEFEKEFRQLNYISIASVSSANNIAKYDVGGFPGPKCPFHIRG
ILTYNRAIKGNIDAPQVVEGEKVYVLPLREGNPFGDKCIAWPSGTEITDL
IKDDVLHWMDYTVLLEKTFIKPLEGFTSAAKLDYEKKASL
Ligand information
Receptor-Ligand Complex Structure
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PDB3rmc A crystallographic study of the role of sequence context in thymine glycol bypass by a replicative DNA polymerase serendipitously sheds light on the exonuclease complex.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		K706 M728 G729 Q733 S735 S783 S784 N786 N787 P802 H804
Binding residue
(residue number reindexed from 1)		K699 M721 G722 Q726 S728 S776 S777 N779 N780 P795 H797
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0004527 exonuclease activity
GO:0008408 3'-5' exonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0039686 bidirectional double-stranded viral DNA replication
GO:0039693 viral DNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:3rmc, PDBe:3rmc, PDBj:3rmc
PDBsum3rmc
PubMed21781974
UniProtQ38087|DPOL_BPR69 DNA-directed DNA polymerase (Gene Name=43)

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