Structure of PDB 3h90 Chain D Binding Site BS02

Receptor Information
>3h90 Chain D (length=283) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LVSRAAIAATAMASLLLLIKIFAWWYTGSVSILAALVDSLVDIGASLTNL
LVVRYSLQPADDNHSFGHGKAESLAALAQSMFISGSALFLFLTGIQHLIS
PTPMTDPGVGVIVTIVALICTIILVSFQRWVVRRTQSQAVRADMLHYQSD
VMMNGAILLALGLSWYGWHRADALFALGIGIYILYSALRMGYEAVQSLLD
RALPDEERQEIIDIVTSWPGVSGAHDLRTRQSGPTRFIQIHLEMEDSLPL
VQAHMVADQVEQAILRRFPGSDVIIHQDPCSVV
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain3h90 Chain D Residue 6 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3h90 Structural basis for autoregulation of the zinc transporter YiiP.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		D68 H71 H75
Binding residue
(residue number reindexed from 1)		D61 H64 H68
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005381 iron ion transmembrane transporter activity
GO:0005385 zinc ion transmembrane transporter activity
GO:0008324 monoatomic cation transmembrane transporter activity
GO:0015086 cadmium ion transmembrane transporter activity
GO:0015093 ferrous iron transmembrane transporter activity
GO:0015297 antiporter activity
GO:0015341 zinc efflux active transmembrane transporter activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0046873 metal ion transmembrane transporter activity
GO:0140826 zinc:proton antiporter activity
Biological Process
GO:0006812 monoatomic cation transport
GO:0006826 iron ion transport
GO:0006829 zinc ion transport
GO:0006879 intracellular iron ion homeostasis
GO:0006882 intracellular zinc ion homeostasis
GO:0034755 iron ion transmembrane transport
GO:0055085 transmembrane transport
GO:0070574 cadmium ion transmembrane transport
GO:0071577 zinc ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Biological Process
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Cellular Component
External links
PDB RCSB:3h90, PDBe:3h90, PDBj:3h90
PDBsum3h90
PubMed19749753
UniProtP69380|FIEF_ECOLI Cation-efflux pump FieF (Gene Name=fieF)

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