Structure of PDB 3gv5 Chain D Binding Site BS02

Receptor Information
>3gv5 Chain D (length=383) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLGV
KKLMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVTELLEEFSPVVERLGF
DENFVDLTEMVEKRLQQLQSDELSAVTVSGHVYNNQSINLLDVLHIRLLV
GSQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPES
CQHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGI
SVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKCSSEVEAKNKIEELL
ASLLNRVCQDGRKPHTVRLIIRRYSSGRESRQCPIPSHVIQKLNYDVMTP
MVDILMKLFRNMVNVKMPFHLTLLSVCFCNLKA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB3gv5 Structural basis of error-prone replication and stalling at a thymine base by human DNA polymerase iota
Resolution2.0 Å
Binding residue
(original residue number in PDB)		Q59 K60 Y61 L62 E97 L99 Y244 Q300 S301 S303 E305 S307 R347 R357
Binding residue
(residue number reindexed from 1)		Q34 K35 Y36 L37 E72 L74 Y219 Q275 S276 S278 E280 S282 R322 R328
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006281 DNA repair

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3gv5, PDBe:3gv5, PDBj:3gv5
PDBsum3gv5
PubMed19440206
UniProtQ9UNA4|POLI_HUMAN DNA polymerase iota (Gene Name=POLI)

[Back to BioLiP]