Structure of PDB 3g93 Chain D Binding Site BS02

Receptor Information
>3g93 Chain D (length=440) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GKLPPGPSPLPVLGNLLQMDRKGLLRSFLRLREKYGDVFTVYLGSRPVVV
LCGTDAIREALVDQAEAFSGRGKIAVVDPIFQGYGVIFANGERWRALRRF
SLATMSVEERIQEEARCLVEELRKSKGALLDNTLLFHSITSNIICSIVFG
KRFDYKDPVFLRLLDLFFQSFSLISSFSSQVFELFSGFLKYFPGTHRQIY
RNLQEINTFIGQSVEKHRATLDPSNPRDFIDVYLLRMEKDHQNLILTVLS
LFFAGTETTSTTLRYGFLLMLKYPHVTERVQKEIEQVIGSHRPPALDDRA
KMPYTDAVIHEIQRLGDLIPFGVPHTVTKDTQFRGYVIPKNTEVFPVLSS
ALHDPRYFETPNTFNPGHFLDANGALKRNEGFMPFSLGKRICLGEGIART
ELFLFFTTILQNFSIASPVPPEDIDLTPVPPSYQIRFLAR
Ligand information
Ligand IDPB2
InChIInChI=1S/C16H14N2/c1-2-4-15(5-3-1)16-8-6-14(7-9-16)12-18-11-10-17-13-18/h1-11,13H,12H2
InChIKeyDLYMRVCQTVOYEW-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1ccc(cc1)c2ccc(cc2)Cn3ccnc3
ACDLabs 10.04n1ccn(c1)Cc3ccc(c2ccccc2)cc3
CACTVS 3.341C(n1ccnc1)c2ccc(cc2)c3ccccc3
FormulaC16 H14 N2
Name1-(biphenyl-4-ylmethyl)-1H-imidazole
ChEMBLCHEMBL1235146
DrugBankDB08369
ZINCZINC000053683112
PDB chain3g93 Chain D Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3g93 Crystal structures of cytochrome P450 2B4 in complex with the inhibitor 1-biphenyl-4-methyl-1H-imidazole: ligand-induced structural response through alpha-helical repositioning.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		A298 G299 T302 I363
Binding residue
(residue number reindexed from 1)		A254 G255 T258 I319
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) T302 F429 C436
Catalytic site (residue number reindexed from 1) T258 F385 C392
Enzyme Commision number 1.14.14.1: unspecific monooxygenase.
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0008392 arachidonate epoxygenase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0020037 heme binding
GO:0046872 metal ion binding
GO:0070330 aromatase activity
Biological Process
GO:0006805 xenobiotic metabolic process
GO:0019373 epoxygenase P450 pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle

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Biological Process
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Cellular Component
External links
PDB RCSB:3g93, PDBe:3g93, PDBj:3g93
PDBsum3g93
PubMed19397311
UniProtP00178|CP2B4_RABIT Cytochrome P450 2B4 (Gene Name=CYP2B4)

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