Structure of PDB 3aoi Chain D Binding Site BS02

Receptor Information
>3aoi Chain D (length=1316) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKKEVRKVRIALASPEKIRSWSYGEVEKPETINYRTLKPERDGLFDERIF
GPIKDVRRYRMGHIELATPAAHIWFVKDVPSKIGTLLDLSATELEQVLYF
SKYIVLDPKGAILNGVPVEKRQLLTDEEYRELRYGKQETYPLPPGVDALV
KDGEEVVKGQELAPGVVSRLDGVALYRFPRRVRVEYRVQPHMNVVVPEGA
RVEAGDKIVAAIDPEEEVIAEAEGVVHLHEPASILVVKARVYPFEDDVEV
STGDRVAPGDVLADGGKVKSDVYGRVEVDLVRNVVRVVESYDIDARMGAE
AIQQLLKELDLEALEKELLEEMKHPSRARRAKARKRLEVVRAFLDSGNRP
EWMILEAVPVLPPDLRPSDLNDLYRRLINRNNRLKKLLAQGAPEIIIRNE
KRMLQEAVDALLDNGRRGAPVTNPGSDRPLRSLTDILSGKQGRFRQNLLG
KRVDYSGRSVIVVGPQLKLHQCGLPKRMALELFKPFLLKKMEEKGIAPNV
KAARRMLERQRDIKDEVWDALEEVIHGKVVLLNRAPTLHRLGIQAFQPVL
VEGQSIQLHPLVCEAFNADFDGDQMAVHVPLSSFAQAEARIQMLSAHNLL
SPASGEPLAKPSRDIILGLYYITQVRKEKKGAGLEFATPEEALAAHERGE
VALNAPIKVAGRETSVGRLKYVFANPDEALLAVAHGIVDLQDVVTVRYMG
KRLETSPGRILFARIVAEAVEDEKVAWELIQLDVPQEKNSLKDLVYQAFL
RLGMEKTARLLDALKYYGFTFSTTSGITIGIDDAVIPEEKKQYLEEADRK
LLQIEQAYEMGFLTDRERYDQILQLWTETTEKVTQAVFKNFEENYPFNPL
YVMAQSGARGNPQQIRQLCGLRGLMQKPSGETFEVPVRSSFREGLTVLEY
FISSHGARKGGADTALRTADSGYLTRKLVDVTHEIVVREADCGTTNYISV
PLFQPDEVTRSLRLRKRADIEAGLYGRVLAREVEVLGVRLEEGRYLSMDD
VHLLIKAAEAGEIQEVPVRSPLTCQTRYGVCQKCYGYDLSMARPVSIGEA
VGIVAAQSIGEPGTQLTDITQGLPRVIELFEARRPKAKAVISEIDGVVRI
EETEEKLSVFVESEGFSKEYKLPKEARLLVKDGDYVEAGQPLTRGAIDPH
QLLEAKGPEAVERYLVEEIQKVYRAQGVKLHDKHIEIVVRQMMKYVEVTD
PGDSRLLEGQVLEKWDVEALNERLIAEGKTPVAWKPLLMGVTKSALSTKS
WLSAASFQNTTHVLTEAAIAGKKDELIGLKENVILGRLIPAGTGSDFVRF
TQVVDQKTLKAIEEAR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3aoi Crystal structure of bacterial RNA polymerase bound with a transcription inhibitor protein
Resolution4.3 Å
Binding residue
(original residue number in PDB)		R704 P706 D741 D743
Binding residue
(residue number reindexed from 1)		R534 P536 D571 D573
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3aoi, PDBe:3aoi, PDBj:3aoi
PDBsum3aoi
PubMed21124318
UniProtQ8RQE8|RPOC_THET8 DNA-directed RNA polymerase subunit beta' (Gene Name=rpoC)

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