Structure of PDB 2vrt Chain D Binding Site BS02

Receptor Information
>2vrt Chain D (length=487) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKRMLINATQQEELRVALVDGQRLYDLDIESPEQKKANIYKGKITRIEPS
LEAAFVDYGAERHGFLPLKEIAREYFPRPNIKDVLREGQEVIVQIDKEER
GNKGAALTTFISLAGSYLVLMPNNPRAGGISRRIEDDRTELKEALASLEL
PEGMGLIVRTAGVGKSAEALQWDLSFRLKHWEAIKKAAESRPAPFLIHQE
SNVIVRAFRDYLRQDIGEILIDNPKVLELARQHIAALGRPDFSSKIKLYT
GEIPLFSHYQIESQIESAFQREVRLPSGGSIVIDSTEALTAIDINSARDI
EETAFNTNLEAADEIARQLRLRDLGGLIVIDFIDMTPVRHQRAVENRLRE
AVRQDRARIQISHISRFGLLEMSRQRLSSHHVCPRCSGTGTVRDNESLSL
SILRLIEEEALKENTQEVHAIVPVPIASYLLNEKRSAVNAIETRQDGVRC
VIVPNDQMETPHYHVLRVRKGEETPTLSYMLPKLHEE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain2vrt Chain D Residue 1509 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2vrt The Crystal Structure of the Escherichia Coli Rnase E Apoprotein and a Mechanism for RNA Degradation.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		C404 C407
Binding residue
(residue number reindexed from 1)		C383 C386
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.26.12: ribonuclease E.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004540 RNA nuclease activity
GO:0008995 ribonuclease E activity
Biological Process
GO:0006396 RNA processing

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2vrt, PDBe:2vrt, PDBj:2vrt
PDBsum2vrt
PubMed18682225
UniProtP21513|RNE_ECOLI Ribonuclease E (Gene Name=rne)

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