Structure of PDB 2vnu Chain D Binding Site BS02

Receptor Information
>2vnu Chain D (length=694) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DFTFPEYYSTARVMGGLKNGVLYQGNIQISEYNFLEGSVSLPRFSKPVLI
VGQKNLNRAFNGDQVIVELLPQSEWKAPSSIVLDSEHFDIQPTAKVVYIQ
RRSWRQYVGQLAPSSVDPQSSSTQNVFVILMDKCLPKVRIRTRRAAELLD
KRIVISIDSWPTTHKYPLGHFVRDLGTIESAQAETEALLLEHDVEYRPFS
KKVLECLPAEGHDWKAPTKLDDPEAVSKDPLLTKRKDLRDKLICSIDPPG
CVDINDALHAKKLPNGNWEVGVHIADVTHFVKPGTALDAEGAARGTSVYL
VDKRIDMLPMLLGTDLCSLKPYVDRFAFSVIWELDDSANIVNVNFMKSVI
RSREAFSYEQAQLRIDDKTQNDELTMGMRALLKLSVKLKQKRLEAGALNL
ASPEVKVHMDSETSDPNEVEIKKLLATNSLVEEFMLLANISVARKIYDAF
PQTAMLRRHAAPPSTNFEILNEMLNTRKNMSISLESSKALADSLDRCVDP
EDPYFNTLVRIMSTRCMMAAQYFYSGAYSYPDFRHYGLAVDIYTHFTSPI
RRYCDVVAHRQLAGAIGYEPLSLTHRDKNKMDMICRNINRKHRNAQFAGR
ASIEYYVGQVMRNNESTETGYVIKVFNNGIVVLVPKFGVEGLIRLDNLTE
DPNSAAFDEVEYKLTFVPTNSDKPRDVYVFDKVEVQVRKRKAEL
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain2vnu Chain D Residue 1500 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2vnu Structure of the Active Subunit of the Yeast Exosome Core, Rrp44: Diverse Modes of Substrate Recruitment in the Rnase II Nuclease Family
Resolution2.3 Å
Binding residue
(original residue number in PDB)		D543 D552
Binding residue
(residue number reindexed from 1)		D247 D256
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) D543 D549 N551 D552
Catalytic site (residue number reindexed from 1) D247 D253 N255 D256
Enzyme Commision number 3.1.13.-
3.1.26.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004540 RNA nuclease activity

View graph for
Molecular Function
External links
PDB RCSB:2vnu, PDBe:2vnu, PDBj:2vnu
PDBsum2vnu
PubMed18374646
UniProtQ08162|RRP44_YEAST Exosome complex exonuclease DIS3 (Gene Name=DIS3)

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