Structure of PDB 2v4o Chain D Binding Site BS02

Receptor Information

>2v4o Chain D (length=258) Species: 99287 (Salmonella enterica subsp. enterica serovar Typhimurium str. LT2)

HGMASMRILLSNDDGVHAPGIQTLAKALREFADVQVVAPDRNRSGASNSL
TLESSLRTFTFDNGDIAVQMGTPTDCVYLGVNALMRPRPDIVVSGINAGP
NLGDDVIYSGTVAAAMEGRHLGFPALAVSLNGYQHYDTAAAVTCALLRGL
SREPLRTGRILNVNVPDLPLAQVKGIRVTRCGSRHPADKVIPQEDPRGNT
LYWIGPPGDKYDAGPDTDFAAVDEGYVSVTPLHVDLTAHSAHDVVSDWLD
SVGVGTQW

Ligand information

• Ligand ID: PO4
• InChI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
• InChIKey: NBIIXXVUZAFLBC-UHFFFAOYSA-K
• SMILES:
  CACTVS 3.341: [O-][P]([O-])([O-])=O
  ACDLabs 10.04: [O-]P([O-])([O-])=O
  OpenEye OEToolkits 1.5.0: [O-]P(=O)([O-])[O-]
• Formula: O4 P
• Name: PHOSPHATE ION
• DrugBank: DB14523
• PDB chain: 2v4o Chain D Residue 1256

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2v4o Structural and Functional Studies on a Mesophilic Stationary Phase Survival Protein (Sur E) from Salmonella Typhimurium
• Resolution: 2.71 Å
• Binding residue (original residue number in PDB): D8 S39 N92 N96 S104 T106
• Binding residue (residue number reindexed from 1): D13 S44 N97 N101 S109 T111
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.1.3.5: 5'-nucleotidase.
  3.1.3.6: 3'-nucleotidase.
  3.6.1.11: exopolyphosphatase.

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0004309 exopolyphosphatase activity
• GO:0008252 nucleotidase activity
• GO:0008253 5'-nucleotidase activity
• GO:0008254 3'-nucleotidase activity
• GO:0016787 hydrolase activity
• GO:0046872 metal ion binding
• GO:0106411 XMP 5'-nucleosidase activity

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:2v4o, PDBe:2v4o, PDBj:2v4o
• PDBsum: 2v4o
• PubMed: 19021761
• UniProt: P66881|SURE_SALTY 5'/3'-nucleotidase SurE (Gene Name=surE)