Structure of PDB 2uuu Chain D Binding Site BS02

Receptor Information
>2uuu Chain D (length=537) Species: 44689 (Dictyostelium discoideum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GAMGSPKEHIDLYQQIKWNGWGDTRKFLHQLKPSGTIAMTTPEVSSVPLP
SLRGFIKKEFVLDETPALQIENIHVDPPKQYPEFVRELKAFFLPDQLKDD
KLARITHTFGKSLRDLIRVRIGQVKNAPDLIVLPHSHEEVERLVQLAHKY
NVVIIPMGGGSNIVGAIEPVSNERFTVSIDMRRMNKVLWVDRREMTACIQ
VGIMGPELEKQLHKQGVSLGHDPDSFEFSTLGGWLATCSSGHQSDKYGDI
EDMAVSFRTVTPTGTLELRAGINYKHIILGSEGTLGIITEAVMKVHAVPQ
AVEYYGFLFPTFAHAVSALQQIRSSEVIPTMIRVYDPEETQLSFAWKPSS
EFTSAMVKKYLHYIRSFDFKNVCLSIIGFEGPKKVVDFHRTSVFDILSKN
AAFGLGSAPGKTWAEKRYDLPYIRDFLLDHNMWVDVAETTVSYANLQTLW
KDAKQTFVKHFKDQGIPAWICAHISHTYTNGVCLYFIFASKQNAQYIEAK
KLMTDIIFKYGGSLGWINVYRSLKETIDPKDICNPRK
Ligand information
Ligand IDPL3
InChIInChI=1S/C16H34O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17/h17H,2-16H2,1H3
InChIKeyBXWNKGSJHAJOGX-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04OCCCCCCCCCCCCCCCC
CACTVS 3.341
OpenEye OEToolkits 1.5.0		CCCCCCCCCCCCCCCCO
FormulaC16 H34 O
NameHEXADECAN-1-OL
ChEMBLCHEMBL706
DrugBankDB09494
ZINCZINC000008214519
PDB chain2uuu Chain D Residue 1587 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2uuu The Crucial Step in Ether Phospholipid Biosynthesis: Structural Basis of a Noncanonical Reaction Associated with a Peroxisomal Disorder.
Resolution1.95 Å
Binding residue
(original residue number in PDB)		L443 W492
Binding residue
(residue number reindexed from 1)		L420 W469
Annotation score1
Enzymatic activity
Enzyme Commision number 2.5.1.26: alkylglycerone-phosphate synthase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008609 alkylglycerone-phosphate synthase activity
GO:0016740 transferase activity
GO:0042802 identical protein binding
GO:0043178 alcohol binding
GO:0050660 flavin adenine dinucleotide binding
GO:0071949 FAD binding
Biological Process
GO:0006629 lipid metabolic process
GO:0008610 lipid biosynthetic process
GO:0008611 ether lipid biosynthetic process
Cellular Component
GO:0005777 peroxisome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2uuu, PDBe:2uuu, PDBj:2uuu
PDBsum2uuu
PubMed17562315
UniProtO96759|ADAS_DICDI Alkyldihydroxyacetonephosphate synthase (Gene Name=eapA)

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