Structure of PDB 2pzs Chain D Binding Site BS02

Receptor Information
>2pzs Chain D (length=564) Species: 10756 (Salasvirus phi29) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PRKMYSCAFETTTKVEDCRVWAYGYMNIEDHSEYKIGNSLDEFMAWVLKV
QADLYFHNLKFAGAFIINWLERNGFKWSADGLPNTYNTIISRMGQWYMID
ICLGYKGKRKIHTVIYDSLKKLPFPVKKIAKDFKLTVLKGDIDYHKERPV
GYKITPEEYAYIKNDIQIIAEALLIQFKQGLDRMTAGSDSLKGFKDIITT
KKFKKVFPTLSLGLDKEVRYAYRGGFTWLNDRFKEKEIGEGMVFDVNSLY
PAQMYSRLLPYGEPIVFEGKYVWDEDYPLHIQHIRCEFELKEGYIPTIQI
KYNEYLKSSGGEIADLWLSNVDLELMKEHYDLYNVEYISGLKFKATTGLF
KDFIDKWTYIKTTSEGAIKQLAKLMLNSLYGKFASNPDVTGKVPYLKENG
ALGFRLGEEETKDPVYTPMGVFITAWARYTTITAAQACYDRIIYCDTDSI
HLTGTEIPDVIKDIVDPKKLGYWAHESTFKRAKYLRQKTYIQDIYMKEVD
GKLVEGSPDDYTDIKFSVKCAGMTDKIKKEVTFENFKVGFSRKMKPKPVQ
VPGGVVLVDDTFTI
Ligand information
Receptor-Ligand Complex Structure
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PDB2pzs Structures of phi29 DNA polymerase complexed with substrate: the mechanism of translocation in B-family polymerases
Resolution2.6 Å
Binding residue
(original residue number in PDB)		I93 Y101 T189 S192 Y226 R227 G228 Q303 K305 N313 G391 K392 N396 R496 Q497 T571 F572 T573 I574
Binding residue
(residue number reindexed from 1)		I89 Y97 T185 S188 Y222 R223 G224 Q299 K301 N303 G381 K382 N386 R486 Q487 T561 F562 T563 I564
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0001882 nucleoside binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0004527 exonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0039693 viral DNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:2pzs, PDBe:2pzs, PDBj:2pzs
PDBsum2pzs
PubMed17611604
UniProtP03680|DPOL_BPPH2 DNA polymerase (Gene Name=2)

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