Structure of PDB 2jh5 Chain D Binding Site BS02

Receptor Information
>2jh5 Chain D (length=250) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKEGQPS
VLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGP
FVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFG
Ligand information
Receptor-Ligand Complex Structure
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PDB2jh5 Sulfonamide-Related Conformational Effects and Their Importance in Structure-Based Design.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		F34 L65 R73 T74 R75 Y76 K81 I82
Binding residue
(residue number reindexed from 1)		F19 L60 R68 T69 R70 Y71 K77 I78
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:2jh5, PDBe:2jh5, PDBj:2jh5
PDBsum2jh5
PubMed17336062
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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