Structure of PDB 2e77 Chain D Binding Site BS02

Receptor Information
>2e77 Chain D (length=368) Species: 1377 (Aerococcus viridans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EYNAPSEIKYIDVVNTYDLEEEASKVVPHGGFNYIAGASGDEWTKRANDR
AWKHKLLYPRLAQDVEAPDTSTEILGHKIKAPFIMAPIAAHGLAHTTKEA
GTARAVSEFGTIMSISAYSGATFEEISEGLNGGPRWFQIYMAKDDQQNRD
ILDEAKSDGATAIILTADSTVSGNRDRDVKNKFVYPFGMPIVQRYLRGTA
EGMSLNNIYGASKQKISPRDIEEIAGHSGLPVFVKGIQHPEDADMAIKRG
ASGIWVSNHGARQLYEAPGSFDTLPAIAERVNKRVPIVFDSGVRRGEHVA
KALASGADVVALGRPVLFGLALGGWQGAYSVLDYFQKDLTRVMQLTGSQN
VEDLKGLDLFDNPYGYEY
Ligand information
Ligand IDPYR
InChIInChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)
InChIKeyLCTONWCANYUPML-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.385CC(=O)C(O)=O
OpenEye OEToolkits 1.7.6CC(=O)C(=O)O
ACDLabs 12.01O=C(C(=O)O)C
FormulaC3 H4 O3
NamePYRUVIC ACID
ChEMBLCHEMBL1162144
DrugBankDB00119
ZINCZINC000001532517
PDB chain2e77 Chain D Residue 3442 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2e77 Crystallographic study on the interaction of L-lactate oxidase with pyruvate at 1.9 Angstrom resolution.
Resolution1.9 Å
Binding residue
(original residue number in PDB)		Y3040 Y3146 R3181 Y3215 H3265 R3268
Binding residue
(residue number reindexed from 1)		Y34 Y140 R175 Y209 H259 R262
Annotation score5
Enzymatic activity
Catalytic site (original residue number in PDB) S3122 Y3146 T3172 D3174 K3241 H3265
Catalytic site (residue number reindexed from 1) S116 Y140 T166 D168 K235 H259
Enzyme Commision number 1.1.3.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004459 L-lactate dehydrogenase activity
GO:0010181 FMN binding
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:2e77, PDBe:2e77, PDBj:2e77
PDBsum2e77
PubMed17517371
UniProtQ44467|LOX_AERVM L-lactate oxidase

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