Structure of PDB 2amf Chain D Binding Site BS02

Receptor Information
>2amf Chain D (length=258) Species: 160490 (Streptococcus pyogenes M1 GAS) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NAMKIGIIGVGKMASAIIKGLKQTPHELIISGSSLERSKEIAEQLALPYA
MSHQDLIDQVDLVILGIKPQLFETVLKPLHFKQPIISMAAGISLQRLATF
VGQDLPLLRIMPNMNAQILQSSTALTGNALVSQELQARVRDLTDSFGSTF
DISEKDFDTFTALAGSSPAYIYLFIEALAKAGVKNGIPKAKALEIVTQTV
LASASNLKTSSQSPHDFIDAICSPGGTTIAGLMELERLGLTATVSSAIDK
TIDKAKSL
Ligand information
Ligand IDPRO
InChIInChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1
InChIKeyONIBWKKTOPOVIA-BYPYZUCNSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C1C[C@H](NC1)C(=O)O
CACTVS 3.341OC(=O)[C@@H]1CCCN1
CACTVS 3.341OC(=O)[CH]1CCCN1
OpenEye OEToolkits 1.5.0C1CC(NC1)C(=O)O
ACDLabs 10.04O=C(O)C1NCCC1
FormulaC5 H9 N O2
NamePROLINE
ChEMBLCHEMBL54922
DrugBankDB00172
ZINCZINC000000895360
PDB chain2amf Chain D Residue 4330 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2amf Crystal Structures of Delta(1)-Pyrroline-5-carboxylate Reductase from Human Pathogens Neisseria meningitides and Streptococcus pyogenes
Resolution2.2 Å
Binding residue
(original residue number in PDB)		I219 S221 G224 T225 T226
Binding residue
(residue number reindexed from 1)		I221 S223 G226 T227 T228
Annotation score5
Enzymatic activity
Enzyme Commision number 1.5.1.2: pyrroline-5-carboxylate reductase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004735 pyrroline-5-carboxylate reductase activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0006561 proline biosynthetic process
GO:0055129 L-proline biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Cellular Component
External links
PDB RCSB:2amf, PDBe:2amf, PDBj:2amf
PDBsum2amf
PubMed16233902
UniProtQ9A1S9

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