Structure of PDB 1zz3 Chain D Binding Site BS02

Receptor Information

>1zz3 Chain D (length=367) Species: 242601 (Alcaligenaceae bacterium FB188) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

AIGYVWNTLYGWVDTGTGSLAAANLTARMQPISHHLAHPDTKRRFHELVC
ASGQIEHLTPIAAVAATDADILRAHSAAHLENMKRVSNLPTGGDTGDGIT
MMGNGGLEIARLSAGGAVELTRRVATGELSAGYALVNPPGHHAPHNAAMG
FCIFNNTSVAAGYARAVLGMERVAILDWDVHHGNGTQDIWWNDPSVLTIS
LHQHLCFPPDSGYSTERGAGNGHGYNINVPLPPGSGNAAYLHAMDQVVLP
ALRAYRPQLIIVGSGFDASMLDPLARMMVTADGFRQMARRTIDCAADICD
GRIVFVQEGGYSPHYLPFCGLAVIEELTGVRSLPDPYHEFLAGMGGNTLL
DAERAAIEEIVPLLADI

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

1zz3 Chain D Residue 1751 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	1zz3 Crystal structure of a bacterial class 2 histone deacetylase homologue
Resolution	1.76 Å
Binding residue (original residue number in PDB)	D180 H182 D268
Binding residue (residue number reindexed from 1)	D179 H181 D267
Annotation score	1

Enzymatic activity

Enzyme Commision number

3.5.1.-

Gene Ontology

	Molecular Function
GO:0004407	histone deacetylase activity
GO:0016787	hydrolase activity
GO:0046872	metal ion binding

	Biological Process
GO:0000122	negative regulation of transcription by RNA polymerase II
GO:0006338	chromatin remodeling

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Molecular Function

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Biological Process

External links

PDB	RCSB:1zz3, PDBe:1zz3, PDBj:1zz3
PDBsum	1zz3
PubMed	16242151
UniProt	Q70I53\|HDAH_ALCSD Histone deacetylase-like amidohydrolase (Gene Name=hdaH)

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