Structure of PDB 1zxy Chain D Binding Site BS02

Receptor Information

>1zxy Chain D (length=344) Species: 2287 (Saccharolobus solfataricus)

MNINEILKKLINKSDLEINEAEELAKAIIRGEVPEILVSAILVALRMKGE
SKNEIVGFARAMRELAIKIDVPNAIDTAGTGGDGLGTVNVSTASAILLSL
VNPVAKHGNRAVSGKSGSADVLEALGYNIIVPPERAKELVNKTNFVFLFA
QYYHPAMKNVANVRKTLGIRTIFNILGPLTNPANAKYQLMGVFSKDHLDL
LSKSAYELDFNKIILVYGEPGIDEVSPIGNTFMKIVSKRGIEEVKLNVTD
FGISPIPIEKLIVNSAEDSAIKIVRAFLGKDEHVAEFIKINTAVALFALD
RVGDFREGYEYADHLIEKSLDKLNEIISMNGDVTKLKTIVVKSS

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 1zxy Chain D Residue 347

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1zxy Structural and mutational analysis of substrate complexation by anthranilate phosphoribosyltransferase from Sulfolobus solfataricus.
• Resolution: 2.56 Å
• Binding residue (original residue number in PDB): D223 E224
• Binding residue (residue number reindexed from 1): D223 E224
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.4.2.18: anthranilate phosphoribosyltransferase.

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0004048 anthranilate phosphoribosyltransferase activity
• GO:0016757 glycosyltransferase activity
• GO:0016763 pentosyltransferase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0000162 tryptophan biosynthetic process

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:1zxy, PDBe:1zxy, PDBj:1zxy
• PDBsum: 1zxy
• PubMed: 16714288
• UniProt: P50384|TRPD_SACS2 Anthranilate phosphoribosyltransferase (Gene Name=trpD)